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Source: http://www.cyberskills.org/baffled-by-payday-cash-loans-get-support-on-this-page.html

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Promising new approach in therapy of pain

ScienceDaily (Dec. 3, 2012) ? The treatment of inflammatory pain can be improved by endogenous opioid peptides acting directly in injured tissue. Scientists at the Charit? -- Universit?tsmedizin Berlin and the Universit? Paris Descartes showed that pain can be successfully treated by targeting immune and nerve cells outside the brain or spinal cord.

The study is published in the current issue of the FASEB Journal.

Inflammatory pain is the most common form of painful diseases. Examples are acute pain after surgery, and chronic pain as in the case of rheumatoid arthritis. However, the treatment of inflammatory pain is often difficult because it rarely responds to conventional therapies. Furthermore, opiates, such as morphine, produce serious side effects including addiction mediated in the brain, while drugs, such as ibuprofen, may cause stomach ulcers, internal bleeding, and cardiovascular complications. The activation of opiate receptors in nerve cells outside the brain or spinal cord can alleviate pain without serious side effects. This can be achieved by synthetic opiates or endogenous opioid peptides, e.g. enkephalins and endorphins. However, these peptides are rapidly inactivated by two major enzymes, aminopeptidase N (APN) and neutral endopeptidase (NEP), which limit their analgesic effects.

The aim of the research group of Prof. Halina Machelska-Stein from the Klinik f?r An?sthesiologie at Campus Benjamin Franklin was to prevent the breakdown of endogenous opioid peptides directly in the inflamed tissue. In an animal model, the group has shown that inflammatory pain can be alleviated if the two enzymes (APN and NEP), responsible for the inactivation of the opioid peptides, were blocked by the selective inhibitors. In preparations from immune or nerve cells, which express these enzymes, the opioid peptides were quickly broken down. This was prevented by the enzyme inhibitors, bestatin, thiorpan and P8B. As a result, the sensation of pain was either markedly reduced or completely disappeared.

"Targeting of endogenous opioid peptides directly in injured tissues might be a promising strategy to treat inflammatory pain without serious side effects," states Prof. Machelska-Stein, explaining the results of the investigation. Furthermore, blocking pain at the site of its origin may prevent excitatory mechanisms in the nervous system, which lead to the development of chronic pain.

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The above story is reprinted from materials provided by Charit? - Universit?tsmedizin Berlin.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. A. Schreiter, C. Gore, D. Labuz, M.-C. Fournie-Zaluski, B. P. Roques, C. Stein, H. Machelska. Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue. The FASEB Journal, 2012; 26 (12): 5161 DOI: 10.1096/fj.12-208678

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/B3Sa2TASCKQ/121203082058.htm

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Record high for global carbon emissions

Public release date: 2-Dec-2012
[ | E-mail | Share ]

Contact: Lisa Horton
l.horton@uea.ac.uk
44-016-035-92764
University of East Anglia

Global carbon dioxide (CO2) emissions are set to rise again in 2012, reaching a record high of 35.6 billion tonnes - according to new figures from the Global Carbon Project, co-led by researchers from the Tyndall Centre for Climate Change Research at the University of East Anglia (UEA).

The 2.6 per cent rise projected for 2012 means global emissions from burning fossil fuel are 58 per cent above 1990 levels, the baseline year for the Kyoto Protocol.

This latest analysis by the Global Carbon Project is published today in the journal Nature Climate Change with full data released simultaneously by the journal Earth System Science Data Discussions.

It shows the biggest contributors to global emissions in 2011 were China (28 per cent), the United States (16 per cent), the European Union (11 per cent), and India (7 per cent).

Emissions in China and India grew by 9.9 and 7.5 per cent in 2011, while those of the United States and the European Union decreased by 1.8 and 2.8 per cent.

Emissions per person in China of 6.6 tonnes of CO2 were nearly as high as those of the European Union (7.3), but still below the 17.2 tonnes of carbon used in the United States. Emissions in India were lower at 1.8 tonnes of carbon per person.

Prof Corinne Le Qur, director of the Tyndall Centre for Climate Change Research and professor at UEA, led the publication of the data. She said: "These latest figures come amidst climate talks in Doha. But with emissions continuing to grow, it's as if no-one is listening to the entire scientific community."

The 2012 rise further opens the gap between real-world emissions and those required to keep global warming below the international target of two degrees.

"I am worried that the risks of dangerous climate change are too high on our current emissions trajectory. We need a radical plan," added Prof Corinne Le Qur.

The analysis published in Nature Climate Change shows significant emission reductions are needed by 2020 to keep two degrees as a feasible goal.

It shows previous energy transitions in Belgium, Denmark, France, Sweden, and the UK have led to emission reductions as high as 5 per cent each year over decade-long periods, even without climate policy.

Lead author Dr Glen Peters, of the Centre for International Climate and Environmental Research in Norway, said: "Scaling up similar energy transitions across more countries can kick-start global mitigation with low costs. To deepen and sustain these energy transitions in a broad range of countries requires aggressive policy drivers."

Co-author Dr Charlie Wilson, of the Tyndall Centre at UEA, added: "Public policies and institutions have a central role to play in supporting the widespread deployment of low carbon and efficient energy-using technologies, and in supporting innovation efforts".

Emissions from deforestation and other land-use change added 10 per cent to the emissions from burning fossil fuels. The CO2 concentration in the atmosphere reached 391 parts per million (ppm) at the end of 2011.

These results lends further urgency to recent reports that current emissions pathways are already dangerously high and could lead to serious impacts and high costs on society. These other analyses come from the International Energy Agency, the United Nations Environment Programme, the World Bank, the European Environment Agency, and PricewaterhouseCoopers.

###

The December edition of Nature Climate Change contains three more research papers from Tyndall Centre authors: 'Equity and state representations in climate negotiations' by Heike Schroeder of UEA; 'Changing Social Contracts in Climate Change Adaptation' with Irene Lorenzoni and Tara Quinn of UEA; and 'Proportionate adaptation' by Jim Hall at Oxford University and colleagues from the Tyndall Centres at Southampton University, Cardiff and UEA.

'The mitigation challenge to stay below two degrees' by G.P. Peters, R.M. Andrew, T. Boden, J.G. Canadell, P. Ciais, C. Le Qur, G. Marland, M.R. Raupach, C. Wilson is published online by Nature Climate Change. http://bit.ly/Qpt3ub (online from Dec 2, 2012, 1800 GMT).

Full details of the methods and data used are presented in: 'The Global Carbon Budget 1959' by C. Le Qur, R. J. Andres, T. Boden, T. Conway, R. A. Houghton, J. I. House, G. Marland, G. P. Peters, G. van der Werf, A. Ahlstrm, R. M. Andrew, L. Bopp, J. G. Canadell, P. Ciais, S. C. Doney, C. Enright, P. Friedlingstein, C. Huntingford, A. K. Jain, C. Jourdain, E. Kato, R. Keeling, K. Klein Goldewijk, S. Levis, P. Levy, M. Lomas, B. Poulter, M. Raupach, J. Schwinger, S. Sitch, B. D. Stocker, N. Viovy, S. Zaehle and N. Zeng, Earth System Science Data Discussions. http://bit.ly/UY8GTQ (online from Dec 2, 2012! , 1800 GMT).

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 2-Dec-2012
[ | E-mail | Share ]

Contact: Lisa Horton
l.horton@uea.ac.uk
44-016-035-92764
University of East Anglia

Global carbon dioxide (CO2) emissions are set to rise again in 2012, reaching a record high of 35.6 billion tonnes - according to new figures from the Global Carbon Project, co-led by researchers from the Tyndall Centre for Climate Change Research at the University of East Anglia (UEA).

The 2.6 per cent rise projected for 2012 means global emissions from burning fossil fuel are 58 per cent above 1990 levels, the baseline year for the Kyoto Protocol.

This latest analysis by the Global Carbon Project is published today in the journal Nature Climate Change with full data released simultaneously by the journal Earth System Science Data Discussions.

It shows the biggest contributors to global emissions in 2011 were China (28 per cent), the United States (16 per cent), the European Union (11 per cent), and India (7 per cent).

Emissions in China and India grew by 9.9 and 7.5 per cent in 2011, while those of the United States and the European Union decreased by 1.8 and 2.8 per cent.

Emissions per person in China of 6.6 tonnes of CO2 were nearly as high as those of the European Union (7.3), but still below the 17.2 tonnes of carbon used in the United States. Emissions in India were lower at 1.8 tonnes of carbon per person.

Prof Corinne Le Qur, director of the Tyndall Centre for Climate Change Research and professor at UEA, led the publication of the data. She said: "These latest figures come amidst climate talks in Doha. But with emissions continuing to grow, it's as if no-one is listening to the entire scientific community."

The 2012 rise further opens the gap between real-world emissions and those required to keep global warming below the international target of two degrees.

"I am worried that the risks of dangerous climate change are too high on our current emissions trajectory. We need a radical plan," added Prof Corinne Le Qur.

The analysis published in Nature Climate Change shows significant emission reductions are needed by 2020 to keep two degrees as a feasible goal.

It shows previous energy transitions in Belgium, Denmark, France, Sweden, and the UK have led to emission reductions as high as 5 per cent each year over decade-long periods, even without climate policy.

Lead author Dr Glen Peters, of the Centre for International Climate and Environmental Research in Norway, said: "Scaling up similar energy transitions across more countries can kick-start global mitigation with low costs. To deepen and sustain these energy transitions in a broad range of countries requires aggressive policy drivers."

Co-author Dr Charlie Wilson, of the Tyndall Centre at UEA, added: "Public policies and institutions have a central role to play in supporting the widespread deployment of low carbon and efficient energy-using technologies, and in supporting innovation efforts".

Emissions from deforestation and other land-use change added 10 per cent to the emissions from burning fossil fuels. The CO2 concentration in the atmosphere reached 391 parts per million (ppm) at the end of 2011.

These results lends further urgency to recent reports that current emissions pathways are already dangerously high and could lead to serious impacts and high costs on society. These other analyses come from the International Energy Agency, the United Nations Environment Programme, the World Bank, the European Environment Agency, and PricewaterhouseCoopers.

###

The December edition of Nature Climate Change contains three more research papers from Tyndall Centre authors: 'Equity and state representations in climate negotiations' by Heike Schroeder of UEA; 'Changing Social Contracts in Climate Change Adaptation' with Irene Lorenzoni and Tara Quinn of UEA; and 'Proportionate adaptation' by Jim Hall at Oxford University and colleagues from the Tyndall Centres at Southampton University, Cardiff and UEA.

'The mitigation challenge to stay below two degrees' by G.P. Peters, R.M. Andrew, T. Boden, J.G. Canadell, P. Ciais, C. Le Qur, G. Marland, M.R. Raupach, C. Wilson is published online by Nature Climate Change. http://bit.ly/Qpt3ub (online from Dec 2, 2012, 1800 GMT).

Full details of the methods and data used are presented in: 'The Global Carbon Budget 1959' by C. Le Qur, R. J. Andres, T. Boden, T. Conway, R. A. Houghton, J. I. House, G. Marland, G. P. Peters, G. van der Werf, A. Ahlstrm, R. M. Andrew, L. Bopp, J. G. Canadell, P. Ciais, S. C. Doney, C. Enright, P. Friedlingstein, C. Huntingford, A. K. Jain, C. Jourdain, E. Kato, R. Keeling, K. Klein Goldewijk, S. Levis, P. Levy, M. Lomas, B. Poulter, M. Raupach, J. Schwinger, S. Sitch, B. D. Stocker, N. Viovy, S. Zaehle and N. Zeng, Earth System Science Data Discussions. http://bit.ly/UY8GTQ (online from Dec 2, 2012! , 1800 GMT).

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-12/uoea-rhf112912.php

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Video: Performers honored at Kennedy Center show

>>> from stairway to heaven to stupid human tricks, the white house saluted the arts last night with the kennedy center honors . honores included actor dustin hoffman and rock band led zeppelin and funny man david letterman and comedian ray romano couldn't resist a little dig at the commander in chief.

>> you want to win the world series , you're down one game to nothing, you keep going, you keep going. do you quit when you're down 1 - 0 in debates? no, no.

>> and because no one can resist a great self-pore tate, past hon honor ee meryl streep cozied up to hillary clinton for a little photo op there. 710:00. back to savannah, matt and al.

>> an eclectic group. thanks very

Source: http://video.today.msnbc.msn.com/today/50054523/

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Japan TV: At least 3 dead after tunnel collapse

Kyodo News / AP

Police officers and firefighters gather at the exit of the Sasago Tunnel on the Chuo Expressway in Otsuki in central Japan on Sunday.

By NBC News staff and wire services

Updated at 5:20 a.m. ET: TOKYO ???A tunnel on a major highway in central Japan collapsed on Sunday, killing at least three people and starting a blaze, Japanese media reported.

Attempts to rescue those still trapped inside the smashed tunnel, which began spewing smoke after concrete ceiling panels fell onto the road, have been interrupted for fear they might trigger another collapse.?

Three bodies have been found so far, television networks Fuji and Asahi said.?

The fire service earlier said at least seven people were unaccounted for in the 2.8-mile tunnel in Yamanashi prefecture, about 50 miles west of Tokyo on the Chou Expressway, a main road connecting the capital to western Japan.

---

The fire service said the blaze was extinguished about 11 a.m. (9 p.m. ET) ?some three hours after the accident occurred. ?

"Dense smoke was coming out as if it covers the entire mountain," witness Kiyoko Toyomura told Japanese news agency Kyodo.?

Motorists described narrow escapes from falling debris, and a long walk through the darkness after abandoning their cars.

Jiji Press / AFP - Getty Images

A screen grab taken from video from highway operator Central Nippon Expressway Company shows a passenger vehicle stopping in front of the collapsed roof inside the highway tunnel.

"When I was driving in the tunnel, concrete pieces fell down suddenly from the ceiling," a man in his 30s told public broadcaster?NHK. "I saw a crushed car catching fire. I was frightened, left my car and walked for about an hour to get out of the tunnel."?

NHK reporter Yoshio Goto, caught in Sunday's accident, hit the accelerator and managed to drive out.

More news from the Asia-Pacific region

"But it was a bit too late and pieces of ceiling fell on my car. I kept pressing the pedal and managed to get out," he said. "Then when I looked around, I saw half of the car ceiling was crushed."

It was the worst such accident in Japan since 1996, when a tunnel collapsed and falling rocks crushed cars and a bus, killing 20 people.?

NBC News's Arata Yamamoto contributed to this report from Reuters.

More world stories from NBC News:

Follow World News from NBCNews.com on Twitter and Facebook

Source: http://worldnews.nbcnews.com/_news/2012/12/01/15606290-highway-tunnel-collapses-in-japan-trapping-vehicles-and-starting-fire?lite

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Chiefs beat Panthers at somber Arrowhead Stadium

KANSAS CITY, Mo. (AP) ? Romeo Crennel stood in the middle of the Kansas City Chiefs' locker room Sunday, the emotion threatening to overcome the good-natured coach.

Chiefs owner Clark Hunt was at his side, offering support. Members of the team hugged each other, the mud smearing with tears on their cheeks. And over along the wall stood the empty locker that once belonged to Jovan Belcher, his jersey still hanging from a hook.

Just one day after the linebacker killed his girlfriend and then turned the gun on himself, the Chiefs banded together to play their finest game of the season, an inspired 27-21 victory over the Carolina Panthers that ended an eight-game losing streak suddenly rendered trivial.

"As far as playing the game, I thought that was the best for us to do, because that's what we do," Crennel said, tears forming in the corners of his eyes. "We're football players and football coaches and that's what we do. We play on Sunday."

According to authorities, Belcher shot his girlfriend multiple times early Saturday at a residence near Arrowhead Stadium, then sped to the team's practice facility and turn the gun on himself as Crennel and general manager Scott Pioli watched in the parking lot.

Pioli walked through the press box before the game and said he was doing "OK."

"It's been an incredibly difficult 24 hours for our family and our entire organization," Hunt said. "We have so many guys on our team and our coaching staff who are really, really hurting."

Chiefs players gathered in the tunnel leading to the field for a brief prayer before their pregame stretching. A few fans in the half-empty stadium held up signs referencing the shootings, and there was a moment of silence to remember all victims of domestic violence.

Kansas City police have not released a motive for the shootings, which claimed the life of Belcher and 22-year-old Kasandra M. Perkins, and left a 3-month-old girl, Zoey, an orphan.

"I'm just trying to get through the rest of today," said the Chiefs' Brady Quinn, who threw his first two touchdown passes in three years. "The emotions of what has taken place will probably hit home for a few guys the next few days, when they realize what's taken place."

Cam Newton threw for 232 yards and three touchdowns for the Panthers (3-9), who were informed the game would be played as scheduled while they were heading to Kansas City on Saturday.

DeAngelo Williams added 67 yards rushing, carrying the load with Jonathan Stewart out with an injury. Steve Smith, Greg Olsen and Louis Murphy caught Carolina's TD passes.

"You definitely feel for them. What they are going through is tragic," Olsen said. "But we have a job to do. Our job is to come here and prepare to win. They wouldn't expect any less."

Peyton Hillis had a touchdown run for Kansas City (2-10), while Tony Moeaki and Jon Baldwin had touchdown catches. Ryan Succop hit a pair of field goals, including a 52-yarder with 4:54 left that forced the Panthers try for a touchdown to steal the win.

Instead, they went three-and-out, and the Chiefs were able to run the clock down to 31 seconds before giving back the ball. Newton completed two quick passes to reach the Carolina 38, but his final heave as time expired was caught by Smith short of the end zone.

Panthers coach Ron Rivera greeted Crennel at midfield and gave him a hug.

"They played an inspired football game," Rivera said. "They did some really good things, and we have to give them credit, because they suffered through a very difficult time."

The emotions were raw even after the kickoff.

Kansas City took the opening possession and marched 74 yards in just six plays, including a 21-yard pass to Dwayne Bowe and a 34-yarder to Baldwin that got the Chiefs to the Carolina 2.

Hillis powered in to score the first touchdown for Kansas City on the opening possession of a game since Dec. 26, 2010. It was also the first touchdown drive engineered by Quinn since December 2009, when he helped the Browns beat the Chiefs at Arrowhead Stadium.

Hillis ran to the sideline after scoring his first touchdown of the season and handed the ball to Crennel, then gave the guy who managed to hold the team together a hug.

The Panthers answered with a long touchdown drive of their own. The big play came when safety Abe Elam watched Olsen haul in a 47-yard pass from Newton for the tying touchdown.

The Chiefs had tacked on a field goal when the Panthers struck again, this time after Newton completed three passes to convert third downs, the last finding Smith in the end zone.

But Kansas City finished off the half with one of its best drives of the year, an 80-yard march that took up the final 7:25. Hillis was stuffed at the line on third-and-goal, and Crennel allowed the clock to hit 2 seconds before calling timeout. On the final play of the half, Quinn saw Moeaki open in the back of the end zone and delivered a soft toss for a 17-14 lead.

Breathing room came late in the third quarter when the Chiefs used 17 plays to go 87 yards on a drive that lasted another 10 minutes. Quinn finished it with a 3-yard touchdown pass to Baldwin.

Carolina mounted a comeback with the opening drive of the fourth quarter, with Newton hitting Murphy on a quick slant route from the 8 to get the Panthers within a field goal. But the Chiefs added their own field goal, and then burned enough of the clock to ensure the victory.

One that allowed the Chiefs to celebrate in the midst of their mourning.

"There were pockets in the game where reality hits you again, and that's sobering," said Chiefs linebacker Andy Studebaker. "I've been telling people, Jovan was like a brother to us. His family was family to us. Our hearts go out to them, man, and the game maybe took our heads off it for a while. It brought us closer as a team today, I think. But it's never going to be easy."

NOTES: Chiefs CB Brandon Flowers (hamstring), S Abe Elam (left leg) and LB Derrick Johnson (left hamstring) left the game with injuries. Carolina lost LB James Anderson (eye), Murphy (foot) and S Sherrod Martin (right knee) during the game. ... Chiefs WR Dwayne Bowe caught four passes to move into third place in franchise history with 413 catches. ... Carolina has attempted 11 FGs this season.

__

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

Source: http://news.yahoo.com/chiefs-beats-panthers-somber-arrowhead-stadium-210737022--spt.html

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Time columnist Joel Stein on Scotch, fatherhood & his favorite ...

Joel Stein's book tour is sponsored by Stark Raving Wine and his Houston appearance at Cottonwood featured a wine pairing competition between a trio of food trucks, so I thought it might be relevant to ask him about what kind of food adventures he had while writing Man Made: A Stupid Quest for Masculinity.

"There's no food component in the book," says Stein, a humor columnist for Time magazine. "I wanted to do really stereotypically masculine stuff . . . I'm a pretty good cook, for stories I've worked in restaurants for a night or two and I was trying to do stuff I didn't know how to do personally."

That list included things like hunting turkeys in Vermont, but not eating a 10 lb. cheeseburger Man vs. Food-style. "That stuff seems kinda pussy to me on some level," says Stein.

?The impulse behind writing Man Made started, Stein explains, when he first saw a sonogram of his child and found out he was having a boy.?

"I did learn how to drink Scotch. I invited a bunch of really wimpy, Jewish, sitcom-writing friends over who couldn't drink alcohol and had a guy come from Macallen and teach us how to drink Scotch. I like Scotch now. I learned you could put a little water or ice cubes in it and that's okay. I learned that it doesn't have to burn and that there's a lot of other flavor once you get past the burn. It's almost like drinking coffee, which I've just started to do. Once you accept that bitter and that burn you can taste other things."

The impulse behind writing Man Made started, Stein explains, when he first saw a sonogram of his child and found out he was having a boy.

"I thought I didn't care what the gender of my child was and as soon as I saw a penis I had not exactly a panic attack, but it was more of a freak-out," he admits. "I realized that a penis would want to go camping, and a penis would want to play baseball and a penis would get in fights, and I wasn't good at that stuff as a kid.? I had an Easy Bake Oven and I had a sticker collection, I had a glass animal collection and I listened to show tunes.

"I was not good at being a boy, so I thought I better learn so that my son, if he was into that stuff, wasn't going to go to the neighbor's dad or the coach to do it with him. Very American Male 101," says Stein.

While in Houston, Stein says he had a great meal at Underbelly on Wednesday and that Chris Shepherd took him to Asian Market for lunch. "It was nice, but I think I would rather have had Gatlin's instead."

Stein appears to have developed an addiction to Gatlin's BBQ last year, when he joined Shepherd at the RodeoHouston World's Barbecue Championship.

"Food & Wine embedded me with the team that won the year before, so I went around with Chris Shepherd to Gatlin's and a bunch of barbecue places. I met with Robb Walsh at his house and he taught me how to use a smoker. It was great. The story is okay but the experience was really great," says Stein. But unfortunately some Texas barbecue wasn't the only thing Stein missed on his brief trip to town.

"You know what I like to do when I'm here? Go to [brunch] at Brennan's. On someone else's dime."

Source: http://houston.culturemap.com/newsdetail/12-02-12-time-columnist-joel-stein-on-scotch-fatherhood-his-favorite-houston-foods/

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